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THIS SITE IS INTENDED FOR US RESIDENTS 18 YEARS AND OLDER.
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This site is intended for US residents 18 years and older

“There is a wide variety of resources available with EMPAVELI. They've been super helpful for me.”

Talk to your doctor about whether EMPAVELI is right for you.

PNH=paroxysmal nocturnal hemoglobinuria.

Tori is an adult with PNH taking EMPAVELI.
Individual experiences may vary.

Resources and tools for your treatment needs

Whether you're starting EMPAVELI or finding your stride on treatment, there's a wide range
of specialized resources, tools, and programs to help you along your journey.

Your direct connection to others living with PNH.

Apellis has created a new support program for people living with PNH. PNH Peer 2 Peer lets people considering EMPAVELI treatment connect directly with someone already on EMPAVELI and share their experiences with PNH diagnosis and treatment.

Of course, these conversations can’t replace those you will need to have directly with your healthcare provider. However, if you have questions or would like to hear from other people living with PNH who have started on EMPAVELI treatment, PNH Peer 2 Peer may be able to help.

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Jillian, Louis, and Emma are adults with PNH taking EMPAVELI.

No obligation
to continue

No cost
to you

8 weeks
of treatment

The EMPAVELI Trial Offer is a program that provides 8 weeks of EMPAVELI treatment at no cost to eligible adults with PNH.

If you and your doctor are ready to try EMPAVELI, you may be eligible for a full 8 weeks of EMPAVELI
at no cost.

The EMPAVELI Trial Offer is a program open to adults with PNH, regardless of insurance coverage or current C5i treatment.* People who have already received EMPAVELI treatment are not eligible for the Trial Offer program. Enrollment is straightforward for you and your doctor, and you’ll have access to support services offered by the ApellisAssist® program. After the trial period, you and your doctor will decide if continuing on EMPAVELI is right for you.

*Terms, conditions, and eligibility requirements apply. Ask your doctor for more information.

If you and your doctor are ready to try EMPAVELI,
you may be eligible to enroll in the Trial Offer program.

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Support When Starting
EMPAVELI Guide
Support When Starting EMPAVELI Guide

A guide that takes you from prescription to your first infusion with information about the support you can expect as you begin treatment with EMPAVELI, and who to contact if you have questions.

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EMPAVELI Treatment Brochure
EMPAVELI Treatment Brochure

A complete guide to understanding EMPAVELI including information on benefits, how it works, and side effects.

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Self-Infusion Guide
Self-Infusion Guide

Step-by-step instructions for preparing and infusing EMPAVELI in a convenient brochure format.

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Travel Guide
Travel Guide

A brochure with helpful information for travel and preparation so that taking trips can be easier.

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Travel Letter
Travel Letter

The EMPAVELI Travel Letter explains the supplies you need to travel with in order to self-infuse EMPAVELI. Presenting this letter to customs and security officials, along with your prescription, will help ensure you move through security easily.

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Frequently Asked Questions (FAQs)
Frequently Asked Questions (FAQs)

Whether you have just started EMPAVELI or if you're considering treatment, you can answer any questions you might have with this document.

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HOME SUITE HOME (HSH) has tools to help you stay organized, store your medication, and get comfortable in your own space

You will have access to these tools once you enroll in the ApellisAssist® program, but they are not required. We hope that you will find them to be a helpful addition to your treatment journey.

download information card

HOME SUITE HOME (HSH) has tools to help you stay organized, store your medication, and get comfortable in your own space

You will have access to these tools once you enroll in the ApellisAssist® program, but they are not required. We hope that you will find them to be a helpful addition to your treatment journey.

download information card

Watch helpful videos on HSH TV to help integrate treatment into your life

We talked to Genevieve Gorder to get her unique tips, advice, and how-to guide to help make your home setup as comfortable as possible. She goes over storage solutions for your supplies, how to build a routine, and how you can set up your space to be more comfortable when you are self-infusing at home.

To stay up to date on the latest videos, be sure to subscribe to the YouTube channel.

Medication Storage
Supplies and Storage
Self-Infusion at Home
A New Treatment Routine
infusion-studio

My Infusion Studio

A case to store all of your non-refrigerated treatment supplies.

refrigirator

Refrigerator Storage

A secure storage solution for your medication cartons.

Apellis-HSH

HSH TV

Expert advice from interior designer Genevieve Gorder on how to set up your at-home treatment area.

The My Infusion Tracker™ app

An app designed to help keep track of your treatment so you never miss a dose. Once enrolled in the ApellisAssist program, your Care Coordinator will provide you with a link to download.

Join our community
Connect with us to learn more about PNH and
find support throughout your treatment journey
Attend EMPAVELI
community events
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Jillian is an adult with PNH taking EMPAVELI.
INDICATION AND IMPORTANT SAFETY INFORMATION

INDICATION AND IMPORTANT SAFETY INFORMATION

What is EMPAVELI® (pegcetacoplan)?

EMPAVELI is a prescription medicine used to treat adults with a disease called paroxysmal nocturnal hemoglobinuria (PNH).

What is the most important information I should know about EMPAVELI?

EMPAVELI is a medicine that can affect your immune system and can lower the ability of your immune system to fight infections.

EMPAVELI may increase your chance of getting serious and life-threatening meningococcal infections that may quickly become life-threatening and cause death if not recognized and treated early.

EMPAVELI may also increase the risk of getting serious infections caused by certain bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type B. Serious infections may quickly become life-threatening and cause death if not recognized and treated early.

  1. You must be vaccinated against these bacteria at least 2 weeks before your first dose of EMPAVELI if you have not already had these vaccines.
  2. If your healthcare provider decides that urgent treatment with EMPAVELI is needed, you should receive the required vaccinations as soon as possible.
  3. If you have not been vaccinated and EMPAVELI therapy must be initiated immediately, you should also receive 2 weeks of antibiotics with your vaccinations.
  4. If you have been vaccinated against these bacteria in the past, you might need additional vaccinations before starting EMPAVELI. Your healthcare provider will decide if you need additional vaccinations.
  5. Vaccines reduce the risk of serious infections, but do not prevent all serious infections. Call your healthcare provider or get emergency medical care right away if you get any of these signs and symptoms of a serious infection:
    • fever with or without shivers or the chills
    • fever and a rash
    • shortness of breath
    • extreme pain or discomfort
    • headache with nausea or vomiting
    • high heart rate
    • headache and a fever
    • headache with a stiff neck or stiff back
    • confusion
    • muscle aches with flu-like symptoms
    • clammy skin
    • eyes sensitive to light

Your healthcare provider will give you a Patient Safety Card about the risk of serious infections. Carry it with you at all times during treatment and for 2 months after your last EMPAVELI dose. It is important to show this card to any healthcare provider to help them diagnose and treat you quickly.

EMPAVELI is only available through a program called the EMPAVELI Risk Evaluation and Mitigation Strategy (REMS). Before you can take EMPAVELI, your healthcare provider must enroll in the EMPAVELI REMS program, counsel you about the risk of serious infections caused by certain bacteria, give you information about the symptoms of serious infections, give you a Patient Safety Card about your risk of serious infections, and make sure that you are vaccinated.

Who should NOT take EMPAVELI?

Do not take EMPAVELI if you:

  • are allergic to pegcetacoplan or any of the ingredients in EMPAVELI.
  • have not been vaccinated against Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type B, unless your healthcare provider decides that urgent treatment with EMPAVELI is needed.
  • have a serious infection caused by the bacteria above.

Before you take EMPAVELI, tell your healthcare provider about all of your medical conditions, including if you:

  • have an infection or fever.
  • are pregnant or plan to become pregnant. EMPAVELI may harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with EMPAVELI and use an effective method of birth control during treatment with EMPAVELI and for 40 days after the last dose.
  • are breastfeeding or plan to breastfeed. It is not known if EMPAVELI passes into your breast milk. You should not breastfeed during treatment with EMPAVELI and for 40 days after the last dose.

Tell your healthcare provider about all the vaccines you receive and medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements which could affect your treatment.

If you stop taking EMPAVELI, your healthcare provider will need to monitor you closely for at least 8 weeks after stopping EMPAVELI. Stopping treatment with EMPAVELI may cause a breakdown of red blood cells due to PNH.

Symptoms or problems that can happen due to red blood cell breakdown include:

  • decreased hemoglobin level in your blood
  • blood in your urine
  • shortness of breath
  • trouble swallowing
  • tiredness
  • pain in the stomach (abdomen)
  • blood clots
  • erectile dysfunction (ED)

What are the possible side effects of EMPAVELI?

EMPAVELI can cause serious side effects including allergic reactions. Allergic reactions can happen during your EMPAVELI infusion. Stop your EMPAVELI infusion and tell your healthcare provider or get emergency medical care right away if you get any of these symptoms during your EMPAVELI infusion:

  • chest pain
  • trouble breathing or shortness of breath
  • swelling of your face, tongue, or throat
  • feel faint or pass out

The most common side effects in people with PNH treated with EMPAVELI include injection-site reactions; infections; diarrhea; pain in the stomach (abdomen); respiratory tract infection; pain in the arms, hands, legs, or feet; low potassium in blood; tiredness; viral infection; cough; joint pain; dizziness; headache; and rash.

These are not all of the possible side effects of EMPAVELI. Tell your healthcare provider about any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information, including Boxed WARNING regarding risk of serious infections, and Medication Guide for additional information.
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