“With EMPAVELI self-infusions, I'm able to travel without interrupting my infusion schedule. I can bring my supplies with me wherever I go.”
See the Instructions for Use for information about how to prepare, infuse, and store your EMPAVELI. Your doctor should show you how to prepare and infuse EMPAVELI before you use it for the first time. When traveling, ensure that EMPAVELI stays at 36°F to 46°F (2°C-8°C). Use EMPAVELI exactly as your doctor tells you. Your doctor will tell you how much and how often to infuse EMPAVELI. Do not infuse more or less than your doctor tells you to.
PNH=paroxysmal nocturnal hemoglobinuria.
Individual experiences may vary.
How to take EMPAVELI
Take your treatment wherever is most convenient for you

EMPAVELI does not require visits to an infusion center

EMPAVELI is a treatment you infuse yourself

You can take EMPAVELI when you are away from home

No need to plan days or vacations around infusion visits
Your healthcare provider should show you how to prepare and infuse EMPAVELI before you use it for the first time. Use EMPAVELI exactly as your healthcare provider tells you.
EMPAVELI is a 1080-mg subcutaneous self-infusion
EMPAVELI is administered using a small, thin needle that goes just under the skin.
EMPAVELI can be self-infused in either 1 or 2 sites—in the abdomen, thighs, hips, or upper arms—based on your preference. See the Instructions for Use for more information.

*If there is an increase in your lactate dehydrogenase (LDH), an enzyme in your blood, your healthcare provider may tell you to take EMPAVELI every 3 days.

Not actual size, for illustration purposes only. Exact needle size may vary for some people with PNH.
What is a subcutaneous infusion?
- Subcutaneous needles reach just under the skin into the fatty layer
- The needle does NOT go into the muscle or vein like intravenous (IV) therapies in an infusion center

For illustration purposes only.
How should I take EMPAVELI?
Before you begin treatment, a healthcare provider should show you how to prepare and infuse EMPAVELI

See the Instructions for Use

If you miss a dose of EMPAVELI, take the missed dose as soon as possible. Take your next dose as regularly planned

Your healthcare provider will tell you how much EMPAVELI to infuse and how often to infuse. Do not infuse more or less than your healthcare provider tells you to

If your healthcare provider decides to stop your treatment with EMPAVELI, follow their instructions for how to stop. Your healthcare provider will monitor you closely for at least 8 weeks after stopping treatment with EMPAVELI for any signs of hemolysis due to PNH
Before starting your treatment journey with EMPAVELI, you will need to get certain vaccines. They help reduce the risk of certain serious infections.
You will be required to receive vaccinations against certain types of bacteria at least 2 weeks prior to taking your first dose of EMPAVELI. You may not need all the vaccines if you have already received them in the past.
When visiting your doctor:
- Bring your vaccination records
- Ask your doctor which vaccines you will need before starting EMPAVELI
Reach out to your doctor if you have any additional questions about starting EMPAVELI.

- For the first 4 weeks, you will receive EMPAVELI and your current dose of eculizumab
- After 4 weeks, STOP eculizumab and only take EMPAVELI
- If you are changing treatment from ravulizumab, you should start taking EMPAVELI no more than 4 weeks after your last dose of ravulizumab
This process helps reduce the risk of hemolysis during your treatment transition.
You will receive support from your healthcare team. Also, Apellis can provide you with support from an Apellis Care Educator (ACE) who is trained to help you learn how to infuse. We're here to help.
1-866-MY-APL-ASSIST (1-866-692-7527)
FROM 8 AM-8 PM ET, MONDAY-FRIDAY
They can also connect you to a PANTHERx® Rare
pharmacist who is on call 24 hours a day.
Learn how to infuse EMPAVELI
Watch the video to learn how to
self-infuse EMPAVELI
Additional tools for your treatment journey
to register you for
the My Infusion Tracker™ app